Continuous lines of basophil/mast cells derived from normal mouse bone marrow

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Science  17 Apr 1981:
Vol. 212, Issue 4492, pp. 333-335
DOI: 10.1126/science.7209531


Nonadherent tissue culture cell lines were established from normal bone marrow of a variety of mouse strains. The lines possessed morphological and histochemical markers of the basophil/mast cell and contained committed stem cells for metachromatic cells. Their derivation from normal marrow and their lack of tumorigenicity despite long-term culture makes these cell lines potentially important for studies of the mechanisms of allergic reactions and inflammation as well as the differentiation pathways involving this subset of hematopoietic cells.