Drug discrimination learning in lead-exposed rats

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Science  01 May 1981:
Vol. 212, Issue 4494, pp. 569-571
DOI: 10.1126/science.7209554


Lead acetate (0.02 or 0.5 percent) was administered to dams throughout the lactation period with half of the litters continuing on lead after weaning. Drug thresholds for d-amphetamine were determined by using the drug-discrimination learning paradigm. All the offspring that had been exposed to lead were less sensitive to the stimulus properties of d-amphetamine irrespective of whether or not they had continued on lead after weaning.