Cholecystokinin antibody injected in cerebral ventricles stimulates feeding in sheep

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Science  08 May 1981:
Vol. 212, Issue 4495, pp. 687-689
DOI: 10.1126/science.7221559


The role of brain cholecystokinin peptides in satiety was further assessed by using antibody to cholecystokinin to reduce cholecystokinin activity in the cerebrospinal fluid of sheep. Food intakes were increased approximately 100 percent during the 2-hour continuous injection of antibody into the cerebrospinal fluid. This supports the hypothesis that, during feeding, cholecystokinin is released into the cerebrospinal fluid, which transports it to the receptors that elicit satiety.