Micromolar calcium stimulates proteolysis and glutamate binding in rat brain synaptic membranes

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Science  22 May 1981:
Vol. 212, Issue 4497, pp. 937-938
DOI: 10.1126/science.7015504


Incubation of cortical synaptic membranes with low concentrations of calcium resulted in a decrease in the amount of a high-molecular-weight doublet protein and an increase in the sodium-independent binding of glutamate. Both effects were blocked by the thiol protease inhibitor leupeptin. These results suggest that calcium-induced proteolysis of membrane components regulates the number of glutamate receptors in neuronal membranes.