Reports

Calcium spike electrogenesis and other electrical activity in continuously cultured small cell carcinoma of the lung

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Science  05 Jun 1981:
Vol. 212, Issue 4499, pp. 1155-1157
DOI: 10.1126/science.6262914

Abstract

Spike electrogenesis, local depolarizing and hyperpolarizing responses, spontaneous rhythmic firing, and alternating resting potentials were measured in cells from a continuously cultured small cell carcinoma of the lung. Spike generation was blocked by MnCl2. In view of this evidence for calcium-spike electrogenesis and previous evidence of secretory activity in these cells, this cell line (DMS 53) can provide a model for the study of excitation-secretion behavior in human neoplastic cells.

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