Intravenous self-administration of nomifensine in rats: implications for abuse potential in humans

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Science  05 Jun 1981:
Vol. 212, Issue 4499, pp. 1167-1168
DOI: 10.1126/science.7195072


Rats acquired and maintained intravenous self-administration of nomifensine, a new antidepressant compound. Additional experiments implicated dopamine-containing neurons in this behavior. These findings, along with the marked pharmacological similarities between nomifensine and such drugs as cocaine and methylphenidate, indicate a potential for nomifensine abuse by humans.