Articles

5-Methylcytosine in eukaryotic DNA

Science  19 Jun 1981:
Vol. 212, Issue 4501, pp. 1350-1357
DOI: 10.1126/science.6262918

Abstract

A small portion of the cytosine residues in the DNA of higher eukaryotes as well as in that of many lowe eukaryotes if methylated. The resulting 5-methylcytosine residues occur in specific in the DNA, usually adjacent to guanine residues on the 3' side. This methylation of eukaryotic DNA has been proposed to function in many ways, including control of transcription, maintenance of chromosome structure, repair of DNA, establishment of preferred sites for mutation, oncogenic transformation, and, in certain systems, protection of DNA against enzymatic degradation.

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