Diethylstilbestrol induces neoplastic transformation without measurable gene mutation at two loci

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Science  19 Jun 1981:
Vol. 212, Issue 4501, pp. 1402-1404
DOI: 10.1126/science.6262919


The frequency with which diethylstilbestrol induces neoplastic transformation and somatic mutation was measured concomitantly in Syrian hamster embryo cells. While diethylstilbestrol was as active as benzo[a]pyrene in inducing transformation, it failed to induce mutations at two conventionally studied loci. These results suggest that diethylstilbestrol may transform cells in the absence of gene mutations.