Niacin Reduces Paraquat Toxicity in Rats

Science  26 Jun 1981:
Vol. 212, Issue 4502, pp. 1510-1512
DOI: 10.1126/science.7233236


Rats poisoned with paraquat benefited from daily niacin therapy. Niacin-treated rats showed delayed and reduced dyspnea. Deaths began approximately 30 hours later. The time required for niacin-treated rats to reach 50 percent mortality increased from 60 to 120 hours, and the dealth rate was reduced form 75 to 55 percent. The benefit by niacin is consistent with the demonstrated role of niacin in preventing cellular decreases of nicotinamide adenine dinucleotide during poisoning of bacteria by paraquat and by hyperbaric oxygen.