Physical dependence on morphine fails to develop during the hibernating state

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Science  26 Jun 1981:
Vol. 212, Issue 4502, pp. 1527-1529
DOI: 10.1126/science.7233241


Physical dependence on morphine occurs in a typical fashion during the active state of the mammalian hibernator Citellus lateralis, but does not occur when morphine exposure is confined to the hibernating state. Morphine exposure during hibernation can produce stereotyped behavior, thus demonstrating partial responsiveness of the central nervous system to opioids during this natural state.