Thyrotropin-releasing hormone improves cardiovascular function in experimental endotoxic and hemorrhagic shock

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Science  10 Jul 1981:
Vol. 213, Issue 4504, pp. 216-218
DOI: 10.1126/science.6787704


Thyrotropin-releasing hormone significantly improved cardiovascular function when it was injected intravenously into conscious rats subjected to experimental endotoxic or hemorrhagic shock. Because thyrotropin-releasing hormone appears to be a "physiologic: opiate antagonist without effects on pain responsiveness, it may provide therapeutic benefits in the treatment of shock or acute hypotension.