Pancreatic islet-acinar cell interaction: amylase messenger RNA levels ar determined by insulin

Science  17 Jul 1981:
Vol. 213, Issue 4505, pp. 351-353
DOI: 10.1126/science.6166044


Pancreatic amylase messenger RNA progressively decreases in rats rendered diabetic with streptozotocin. Insulin reverses this effect, inducing a selective decrease in amylase messenger RNA in the pancreas. Parotid amylase messenger RNA is not significantly affected by either diabetes or insulin.