Bee venom enhances guanylate cyclase activity

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Science  17 Jul 1981:
Vol. 213, Issue 4505, pp. 359-360
DOI: 10.1126/science.6113689


Bee venom and phospholipase A2 extracted from bee venom enhanced guanylate cyclase (E.C. activity two- to threefold in rat liver, lung, heart, kidney, ileum, and cerebellum. Dose-response relationships revealed that bee venom at concentrations as low as 1 microgram per milliliter and phospholipase A2 at 1 microunit per milliliter caused a maximal enhancement of guanylate cyclase.