Viral epitopes and monoclonal antibodies: isolation of blocking antibodies that inhibit virus neutralization

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Science  24 Jul 1981:
Vol. 213, Issue 4506, pp. 447-449
DOI: 10.1126/science.6264601


The inability of pathogenic animal viruses to be completely neutralized by antibodies can lead to chronic viral infections in which infectious virus persists even in the presence of excess neutralizing antibody. A mechanism that results in this nonneutralized fraction of virus was defined by the topographical relationships of viral epitopes identified with monoclonal antibodies wherein monoclonal antibodies bind to virus and sterically block the binding of neutralizing antibodies.