Evaluation of nitrate synthesis by intestinal microorganisms in vivo

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Science  24 Jul 1981:
Vol. 213, Issue 4506, pp. 449-450
DOI: 10.1126/science.7244641


The nitrate balance of germfree and conventional rats was assessed to determine whether the intestinal flora produces nitrate in vivo. The results indicate that there can be excess nitrate in the urine of germfree as well as conventional rats. This nitrate is apparently of host origin, and the presence of intestinal flora decreases the output of nitrate in urine.