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Falciparum malaria-infected erythrocytes specifically bind to cultured human endothelial cells

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Science  31 Jul 1981:
Vol. 213, Issue 4507, pp. 555-557
DOI: 10.1126/science.7017935

Abstract

Erythrocytes infected with the late stages of the human malarial parasite Plasmodium falciparum became attached to a subpopulation of cultured human endothelial cells by knoblike protrusions on the surface of the infected erythrocytes. Infected erythrocytes did not bind to cultured fibroblasts; uninfected erythrocytes did not bind to either endothelial cells or fibroblasts. The results suggest a specific receptor-ligand interaction between endothelial cells and a component, components, in the knobs of the infected erythrocytes.