Copper deficiency suppresses the immune response of mice

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Science  31 Jul 1981:
Vol. 213, Issue 4507, pp. 559-561
DOI: 10.1126/science.7244654


Mice fed a purified diet low in copper display anemia, hypoceruloplasminemia, depressed concentrations of liver copper, and elevated concentrations of liver iron. An impaired humoral-mediated immune response (decreased numbers of antibody-producing cells) is observed in mice with severe as well as marginal copper deficiency. The magnitude of this impairment is highly correlated with the degree of functional copper deficiency (hypoceruloplasminemia).

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