Pineal N-acetyltransferase is inactivated by disulfide-containing peptides: insulin is the most potent

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Science  31 Jul 1981:
Vol. 213, Issue 4507, pp. 571-573
DOI: 10.1126/science.7017937


Pineal N-acetyltransferase can be inactivated in broken cell preparations by cystamine through a mechanism of thiol-disulfide exchange. Some, but not all, disulfide-containing peptides can inactivate this enzyme; the most potent inactivator is insulin. These findings suggest that a disulfide-containing peptide with high reactivity toward N-acetyltransferase may participate in the intracellular regulation of this enzyme.