Tumor cell killing by phorbol ester--differentiated human leukemia cells

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Science  07 Aug 1981:
Vol. 213, Issue 4508, pp. 655-657
DOI: 10.1126/science.7196085


The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate causes differentiation of cells of the human leukemia cell line HL60 to nondividing macrophage-like cells. These differentiated cells are cytotoxic for tumor cells (including parent, untreated HL60 cells) in vitro. Agents that induce this desirable differentiation to nondividing, antitumor effector cells may be useful in the experimental treatment of leukemia.