Hyperkeratosis induced by sunlight degradation products of the major polybrominated biphenyl in Firemaster

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Science  21 Aug 1981:
Vol. 213, Issue 4510, pp. 901-902
DOI: 10.1126/science.6266016


Sunlight photodegradation of 2,2', 4,4', 5,5' -hexabromobiphenyl, the major component of Firemaster, gave a mixture that produces severe hyperkeratosis of the rabbit ear. This component in its pure state does not cause hyperkeratosis. One or more of the four major photolysis products must be responsible for this activity. A similar photodegradation pattern was observed for 2,2', 3,4,4', 5,5' -heptabromobiphenyl, the second largest component of Firemaster.