Pesticides: Insecticides and Fungicides Are Chitin Synthesis Inhibitors

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Science  21 Aug 1981:
Vol. 213, Issue 4510, pp. 905-907
DOI: 10.1126/science.213.4510.905


Several important groups of fungicides and insecticides are specific inhibitors of chitin synthesis in a Phycomyces enzyme system and in insect organ cultures. The recently discovered benzoylphenylurea insecticides, which prevent chitin synthesis in insect tissues, are apparently not direct-acting chitin synthetase inhibitors. These insecticides may prevent insect chitin synthesis by interfering with the proteolytic activation of the chitin synthetase zymogen.