Cerebroventricular propranolol elevates cerebrospinal fluid norepinephrine and lowers blood pressure

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Science  21 Aug 1981:
Vol. 213, Issue 4510, pp. 911-913
DOI: 10.1126/science.7256285


Ventriculocisternal administration of dl- and d-propranolol produced dose-dependent increases in cerebrospinal fluid norepinephrine and reductions in blood pressure. A highly significant correlation was found between the increase in norepinephrine and the hypotensive effect. The propranolol-induced hypotension was prevented by intracisternal phentolamine. These data indicate that the hypotensive effect of centrally administered propranolol results from a drug-induced release of norepinephrine, which stimulates central alpha receptors to lower arterial pressure.