Depolarization- and ionophore-induced release of octacosa somatostatin from stalk median eminence synaptosomes

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Science  21 Aug 1981:
Vol. 213, Issue 4510, pp. 913-915
DOI: 10.1126/science.6114560


Species of somatostatin of higher molecular weight were present in the nerve terminals (synaptosomes) of ovine stalk median eminences and were released by depolarizing stimuli. One of these species was identified as the biologically active molecule octacosa somatostatin. Octacosa somatostatin appears therefore to be secreted into the hypothalamic-hypophyseal system, supporting the concept of a role for this peptide in regulating pituitary hormone secretion.