Hyperthermia-induced seizures in the rat pup: a model for febrile convulsions in children

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Science  28 Aug 1981:
Vol. 213, Issue 4511, pp. 1034-1036
DOI: 10.1126/science.7268407


Seizures were produced in rat pups by ambient hyperthermia. Seizure threshold temperatures, measured rectally and intracerebrally, increased between 2 and 10 days of age. Electrocortical paroxysmal discharges were confirmed in hyperthermic 6- and 10-day-old pups. The increasing resistance to hyperthermic seizures with maturation and the electroencephalographic changes induced by hyperthermia are similar to those in young children.