Reports

Immunohistochemical demonstration of a testicular substance related to luteinizing hormone-releasing hormone

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Science  11 Sep 1981:
Vol. 213, Issue 4513, pp. 1263-1264
DOI: 10.1126/science.7022653

Abstract

A substance related to luteinizing hormone-releasing hormone was demonstrated, by immunohistochemical procedures, in the cytoplasm of interstitial cells within the rat testes. In many seminiferous tubules, nuclei of spermatogonial cells were also immunopositive. Both cytoplasmic and nuclear fractions of testicular homogenates contain immunoreactive compounds, and this report identifies which cell types contain this substance. The localization of a peptide hormone within the nucleus of a target cell population may indicate its mode of action.