Phosphorylation of smooth muscle myosin: evidence for cooperativity between the myosin heads

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Science  18 Sep 1981:
Vol. 213, Issue 4514, pp. 1383-1385
DOI: 10.1126/science.6455737


The relationship between the actin-activated adenosinetriphosphatase activity of smooth muscle myosin and the extent of myosin light chain phosphorylation is nonlinear. It is suggested that the phosphorylation of the two heads of smooth muscle myosin is an ordered process and that the two heads are influenced by cooperative interactions.