Recent developments in nuclear magnetic resonance spectroscopy

See allHide authors and affiliations

Science  16 Oct 1981:
Vol. 214, Issue 4518, pp. 291-299
DOI: 10.1126/science.6169151


Nuclear magnetic resonance spectroscopy is a powerful and versatile technique that yields information related to molecular structure, interactions, and dynamics. Methods are currently being developed for real-time monitoring of metabolic processes in vivo and for noninvasive detection of disease and abnormality in living animals. Other nuclear magnetic resonance techniques are providing entirely new approaches for analyses of complex chemical systems. The increased power and popularity of nuclear magnetic resonance spectroscopy today are due to many developments in instrumentation and methods that have occurred over the 35-year history of the technique. The most important single advance, particularly in recent years, has been increased sensitivity. Concurrent improvements in effective spectral resolving power and an array of new methods and applications have also contributed to elevating nuclear magnetic resonance spectroscopy to its present position as one of the premier analytical techniques.