Supraoptic nucleus of the Brattleboro rat has an altered afferent noradrenergic input

Science  16 Oct 1981:
Vol. 214, Issue 4518, pp. 347-349
DOI: 10.1126/science.7053181


The distribution of fluorescent varicosities in the supraoptic nucleus of Brattleboro rats was compared to that in normal rats. The Brattleboro rat, which is characterized by a genetic absence of vasopressin, had fewer fluorescent varicosities in apposition to the vasopressin-deficient perikarya. The oxytocin-producing neurons in the same nucleus were hyperinnervated. These data suggest that the target neuron peptide (vasopressin) is necessary for the maintenance of normal noradrenergic innervation patterns.