Choline stimulates nicotinic receptors on adrenal medullary chromaffin cells to induce catecholamine secretion

Science  23 Oct 1981:
Vol. 214, Issue 4519, pp. 466-468
DOI: 10.1126/science.7291988


Choline stimulated secretion of catecholamines from primary dissociated cultures of bovine adrenal medullary chromaffin cells by interacting with nicotinic receptors. Secretion was readily detected at a choline concentration of 1 millimole per liter and was maximal at 3 to 10 millimoles per liter; it was completely calcium-dependent. Further analysis suggested that choline acts as a partial nicotinic agonist.