Fc and C3b receptors on pulmonary endothelial cells: induction by injury

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Science  30 Oct 1981:
Vol. 214, Issue 4520, pp. 557-558
DOI: 10.1126/science.6270789


Receptors for the activated third component of complement and for the Fc portion of immunoglobulin G are not expressed by apparently normal bovine pulmonary endothelial cells, but are expressed when the cells are exposed to white cell lysates or are infected with influenza or cytomegalovirus. The unmasking of these latent receptors may contribute to the pulmonary inflammatory response characteristic of, for example, anaphylaxis and to those lung diseases characterized by the deposition of immune complexes.