Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamine

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Science  30 Oct 1981:
Vol. 214, Issue 4520, pp. 558-559
DOI: 10.1126/science.7291992


Over the course of 20 weeks, Sprague-Dawley rats developed intestinal tumors in response to an intraperitoneal injection of the acetate derivative of dimethylnitrosamine. The same agent did not induce tumors in Lobund-Wistar rats. The number of tumors was significantly smaller in rats given drinking water containing indomethacin (beginning 14 days after the injections) than in control rats given drug-free water.