Melatonin: identification of sites of antigonadal action in mouse brain

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Science  13 Nov 1981:
Vol. 214, Issue 4522, pp. 821-823
DOI: 10.1126/science.7292016


Long-term implants releasing a small quantity of melatonin (45 nanograms per day) were used to determine the brain sites of the hormone's antigonadal action in a photoperiodic species, the white-footed mouse (Peromyscus leucopus). Implants in the medial preoptic and supra- and retrochiasmatic areas elicited completed gonadal regression after 7 weeks. Implants in other brain regions had little effect on the animals' reproductive state.