Tetrahydrobiopterin in striatum: localization in dopamine nerve terminals and role in catecholamine synthesis

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Science  20 Nov 1981:
Vol. 214, Issue 4523, pp. 919-921
DOI: 10.1126/science.6117945


The hydroxylase cofactor, tetrahydrobiopterin, and its biosynthetic system are localized in dopaminergic nerve terminals in the striatum. This conclusion is based on the nearly equivalent loss of tyrosine hydroxylase and tetrahydrobiopterin and its initial biosynthetic enzyme, guanosine triphosphate cyclohydrolase, after injection of 6-hydroxydopamine into the substantia nigra. The role of the hydroxylase cofactor in the regulation of dopamine synthesis is reassessed.