Dopamine receptor binding is increased in diabetic rats

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Science  27 Nov 1981:
Vol. 214, Issue 4524, pp. 1031-1033
DOI: 10.1126/science.6458088


The binding of [3H]spiperone, a dopamine receptor ligand, to striatal membranes was increased 30 to 35 percent in rats made diabetic with alloxan or streptozotocin. Binding of [3H]spiperone was normal in rats made diabetic with alloxan but treated with insulin. Thus the number of dopamine receptors and central dopaminergic transmission may be altered in diabetes.