Reports

Reduction in oocyte number following prenatal exposure to a diet high in galactose

See allHide authors and affiliations

Science  04 Dec 1981:
Vol. 214, Issue 4525, pp. 1145-1147
DOI: 10.1126/science.7302587

Abstract

When pregnant rats were fed a 50 percent galactose diet there was a striking reduction in oocyte number in the offspring. The most prominent effects were noted after exposure to galactose during the premeiotic stages of oogenesis. Prenatal exposure to galactose or its metabolites may contribute to the premature ovarian failure characteristic of human galactosemia.