Autoimmune encephalomyelitis: simultaneous identification of T and B cells in the target organ

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Science  11 Dec 1981:
Vol. 214, Issue 4526, pp. 1251-1253
DOI: 10.1126/science.7029715

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Monoclonal antibodies to guinea pig T cells and antibodies to guinea pig immunoglobulin G were used in immunofluorescence studies to identify T and B cells in central nervous system tissue from guinea pigs with acute autoimmune encephalomyelitis. T cells appeared before B cells and were distributed within the white matter parenchyma, while B cells remained in perivascular spaces.