Intracranial self-stimulation in 3-day-old rat pups

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Science  18 Dec 1981:
Vol. 214, Issue 4527, pp. 1366-1368
DOI: 10.1126/science.6975999


Three-day-old rat pups with electrodes directed at the medial forebrain bundle at the level of the lateral hypothalamic area were trained to push a paddle to receive electrical brain stimulation. Pups receiving stimulation that was contingent on lifting the paddle responded more frequently than did control pups and also learned a two-choice spatial discrimination task that was rewarded with brain stimulation. The experiments indicate that a neural substrate in the area of the medial forebrain bundle is involved in the central mediation of reinforcement in the rat pup.