Epinephrine reduction of heme: implication for understanding the transmission of an agonist stimulus

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Science  01 Jan 1982:
Vol. 215, Issue 4528, pp. 71-73
DOI: 10.1126/science.6274020


Alpha-adrenergic agonists that promote platelet aggregation were found to reduce ferric heme to ferrous heme. Agents that bind iron in heme inhibited epinephrine-induced platelet aggregation. It is proposed that epinephrine first binds to its receptor and then reduces an adjacent heme group to transmit its agonist stimulus.