Coupling of histone and DNA synthesis in the somatic cell cycle

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Science  01 Jan 1982:
Vol. 215, Issue 4528, pp. 79-81
DOI: 10.1126/science.7053561


The coupling of histone and DNA synthesis was examined in the temperature-sensitive hamster fibroblast cell line K12. By monitoring total cellular histone synthesis at various times after quiescent cells were stimulated to proliferate at permissive and nonpermissive temperatures, a direct correlation was found between the rates of DNA and histone synthesis. Furthermore, when DNA synthesis was blocked by the K12 mutation, histone synthesis was reduced to the basal rate.