beta, gamma-Peroxy analogs of adenosine and guanosine triphosphate: synthesis and biological activity

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Science  01 Jan 1982:
Vol. 215, Issue 4528, pp. 81-82
DOI: 10.1126/science.7053563


Extended analogs of adenosine triphosphate (ATP) and guanosine triphosphate (GTP), in which a peroxide bridge replaces the terminal bridge-oxygen of the triphosphate chain, have been synthesized. The ability of beta, gamma-peroxy-ATP to inhibit or substitute for ATP in representative enzyme systems and that of beta, gamma-peroxy-GTP, for FTP in protein synthesis was tested.