Expression of bovine leukemia virus genome is blocked by a nonimmunoglobulin protein in plasma from infected cattle

Science  22 Jan 1982:
Vol. 215, Issue 4531, pp. 405-407
DOI: 10.1126/science.6276975


Plasma of cattle infected with bovine leukemia virus contains a soluble factor that blocks the expression of the viral genome in cultured lymphocytes. The blocking factor is not present in plasma of bovine leukemia virus-free cattle or of cattle infected with common bovine viruses. Blocking of bovine leukemia virus expression by the plasma factor is reversible, and seems to be mediated by a nonimmunoglobulin protein molecule.