Molecular weight of human gamma interferon is similar to that of other human interferons

See allHide authors and affiliations

Science  22 Jan 1982:
Vol. 215, Issue 4531, pp. 411-413
DOI: 10.1126/science.6173921


The molecular weight (as determined by molecular sieve chromatography) of human gamma interferon, formerly referred to as immune or type II interferon, is between 40,000 and 70,000. On sodium dodecyl sulfate-polyacrylamide gel electrophoresis, gamma interferon activity was recovered mainly from two regions of the gels corresponding to molecular weights of 20,000 and 25,000. The results suggest that in native form human gamma interferon may be aggregated.