Synapses between neurons regenerate accurately after destruction of ensheathing glial cells in the leech

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Science  05 Mar 1982:
Vol. 215, Issue 4537, pp. 1260-1262
DOI: 10.1126/science.7058345


Individual glial cells that ensheathe axons in the central nervous system of the leech were destroyed by intracellular injection of protease. The axons were then severed, and regeneration by particular neurons was studied physiologically and morphologically. Although certain axons sprouted more in the absence of the glial cell, functional synapses were accurately regenerated with normal frequency.