Transplantation of the Cockroach Circadian Pacemaker

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Science  02 Apr 1982:
Vol. 216, Issue 4541, pp. 73-75
DOI: 10.1126/science.216.4541.73


Surgical removal of the optic lobes of the cockroach Leucophaea maderae followed by transplantation of the optic lobes from another individual led to a restoration of the circadian activity rhythm in 4 to 8 weeks. The free-running period of the restored rhythm was determined by the period of the donor rhythm before surgery. The results suggest that the transplanted optic lobe contains a circadian clock that regenerates those neural connections with the host brain that are necessary to drive the circadian rhythm of activity.