Pregnancy suppression by active immunization against gestation-specific riboflavin carrier protein

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Science  09 Apr 1982:
Vol. 216, Issue 4542, pp. 191-193
DOI: 10.1126/science.7063879


A riboflavin carrier protein isolated from chickens cross-reacts with a gestation-specific rodent carrier for riboflavin. Active immunization of female rats of proved fertility with the purified chicken carrier protein completely yet reversibly suppressed early pregnancy without impairing implantation per se. Concurrently there were no discernible adverse effects on maternal health in terms of weight gain, vitamin status, and fertility.