Substance P and cholecystokinin-like peptides in Helix neurons and cholecystokinin and serotonin in a giant neuron

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Science  23 Apr 1982:
Vol. 216, Issue 4544, pp. 409-411
DOI: 10.1126/science.6176023


Immunohistochemical procedures revealed that the serotonin-containing cell situated in each metacerebral ganglion of the snail Helix also contains a cholecystokinin-like peptide, but is devoid of substance P. In radioimmunoassays the cholecystokinin-like material showed similarities to the carboxy terminal regions of mammalian cholecystokinin and gastrin. Since much is known about the morphology and synaptic connections of this serotonin neuron, the role of the cholecystokinin-like peptides can now be investigated by neurophysiological methods, thus opening the way to discovering whether a neuron can use more than one transmitter.