Calcium and age in fibroblasts from control subjects and patients with cystic fibrosis

See allHide authors and affiliations

Science  23 Apr 1982:
Vol. 216, Issue 4544, pp. 417-419
DOI: 10.1126/science.7071590


Intracellular calcium increases significantly as human fibroblasts age in culture. The calcium increase occurs 5 to 6 weeks (passages) earlier and is significantly greater in fibroblasts from subjects with cystic fibrosis in comparison with cells from control subjects. Intracellular calcium, which is thought to be a pathogenetic factor in cystic fibrosis, may also be a meaningful marker in cell aging.