Neuronal cell Thy-1 glycoprotein: homology with immunoglobulin

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Science  14 May 1982:
Vol. 216, Issue 4547, pp. 696-703
DOI: 10.1126/science.6177036


The amino acid sequences of mouse brain Thy-1 glycoproteins are shown to be homologous to those of variable-region immunoglobulin domains. There is also good homology with constant domains and beta 2-microglobulin; overall the results suggest that Thy-1 may be like the primordial immunoglobulin domain. Preliminary evidence for an invertebrate Thy-1 homolog supports this possibility.