Autoradiographic evidence for a calcitonin receptor on testicular Leydig cells

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Science  14 May 1982:
Vol. 216, Issue 4547, pp. 735-736
DOI: 10.1126/science.6281881


Previous studies have indicated that there is a relation between testicular function and adequate concentrations of zinc in testicular cells, and that calcitonin alters cellular zinc transfer in the testis. The present studies provide autoradiographic evidence that calcitonin binds in vivo to the cell membrane of testicular Leydig cells. The data thus confirm the presence of the testicular cell membrane calcitonin receptors that were previously demonstrated indirectly by Scatchard analysis of data collected from binding studies.