Suicide transport: destruction of neurons by retrograde transport of ricin, abrin, and modeccin

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Science  21 May 1982:
Vol. 216, Issue 4548, pp. 889-890
DOI: 10.1126/science.6177039


Certain toxic lectins, including ricin, are retrogradely transported along neuronal processes to the cell body where they inactivate ribosomes, resulting in neuronal death. This process of "suicide transport" suggests a powerful new experimental strategy for solving neurobiological problems.