Reports

Suicide transport: destruction of neurons by retrograde transport of ricin, abrin, and modeccin

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Science  21 May 1982:
Vol. 216, Issue 4548, pp. 889-890
DOI: 10.1126/science.6177039

Abstract

Certain toxic lectins, including ricin, are retrogradely transported along neuronal processes to the cell body where they inactivate ribosomes, resulting in neuronal death. This process of "suicide transport" suggests a powerful new experimental strategy for solving neurobiological problems.